เภสัชกรรมฟื้นฟูสภาวะเสื่อม Regenerative Pharmacy

Pharmacy Challenges in the 21st Century

ยาที่ออกฤทธิ์ต่อเซลล์ต้นกำเนิด

Pros:

Effects of statins on regeneration of olfactory epithelium. Am J Rhinol Allergy. 2010 Mar;24(2):121-5.

Enhanced Oligodendrogenesis and Recovery of Neurological Function by Erythropoietin After Neonatal Hypoxic/Ischemic Brain Injury. Stroke. 2010 Apr 1.

The Novel Antidepressant Agomelatine Normalizes Hippocampal Neuronal Activity and Promotes Neurogenesis in Chronically Stressed Rats. CNS Neurosci Ther. 2010 Mar 11. [Epub ahead of print]

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors. Mol Psychiatry. 2010 Feb 23. [Epub ahead of print]

Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology. 2010 May;58(6):940-9. Epub 2010 Feb 9.

Ageing abolishes the effects of fluoxetine on neurogenesis. Mol Psychiatry. 2009 Sep;14(9):856-64. Epub 2009 Jan 13.

Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil. Behav Brain Res. 2010 Mar 17;208(1):112-7. Epub 2009 Nov 13.

High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling – Results from a randomized, double-blind, and placebo-controlled study. Int J Cardiol. 2010 Mar 15.

Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice. Atherosclerosis. 2009 Jul;205(1):63-73. Epub 2008 Nov 25.

Cons:

Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation. 2010 Feb 9;121(5):675-83. Epub 2010 Jan 25.

Limbal stem cell deficiency after topical mitomycin C therapy for primary acquired melanosis with atypia. Ophthalmology. 2010 Mar;117(3):431-7. Epub 2010 Jan 8.

Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function. Circulation. 2010 Jan 19;121(2):276-92. Epub 2009 Dec 28.

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